Integrative System Biology Laboratory

Dr. Hsien-Da Huang ( 黄宪达 )

Professor,
Co-executive Director,
Warshel Institute for Computational Biology,
School of Life and Health Sciences and School of Science and Engineering,
The Chinese University of Hong Kong, Shenzhen

Research interests:
- » Interdisciplinary biological research
- » Bioinformatics, computational biology, and systems biology
- » Development of biological databases and tools
- » MicroRNAs and small RNAs
- » Protein post-translational modifications
- » Integrative analysis for microarray and next-generation sequencing data in conducting many biological applications and biomedical studies
- » Clinical Bioinformatics
- » Identifying novel biomarkers for diagnosis
E-mail:
- » huanghsienda@cuhk.edu.cn
Phone:
- » +86 (0) 755 2351 9601

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Publications » 2013

Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways.
A. Weiberg, M. Wang, F.M. Lin, H.W. Zhao, Z.H. Zhang, I. Kaloshian, H.D. Huang, and H. Jin*
Science. 2013 Oct 4;342(6154):118-23.
YjcC, a c-di GMP phosphodiesterase protein, regulates the oxidative stress response and virulence of Klebsiella pneumoniae CG43
C.J. Huang, Z.C. Wang, H.Y. Huang, H.D. Huang, and H.L. Peng*
PLoS One. 2013 Jul 23;8(7):e66740.
COL11A1 Promotes Tumor Progression, and Predicts Poor Clinical Outcome in Ovarian Cancer
Y.H. Wu, T.H. Chang, Y.F. Huang, H.D. Huang* and C.Y. Chou*
Oncogene. 2014 Jun 26;33(26):3432-40.
Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility
H. Xiao, M. Lu, T.Y. Lin, Z. Chen, G. Chen, W.C. Wang, T. Marin, T.P. Shentu, L. Wen, B. Gongol, W. Sun, X. Liang, J. Chen, H.D. Huang, J.H. Pedra, D.A. Johnson, and J.Y. Shyy*
Circulation. 2013 Aug 6;128(6):632-42.
Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
Y.C. Tseng, C.F. Lee, Y.S. Li, Y.R. Chen, P.W. Hsiao, M.Y. Chan, F.M. Lin, H.D. Huang, Y.T. Chen, Y.M. Jeng, C.H. Hsu, Q. Yan, M.D. Tsai, and L.J. Juan*
Cancer Research. 2013 Aug 1;73(15):4711-21.
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis
Z. Chen, W.C. Wang, H. Xiao, Y.T. Wang, F.M. Lin, W. Sun, T.C. Lai, Y.H. Jan, Y.S. Li, X. Cui, T. Fang, H. Zhao, C. Padmanabhan, R. Sun, D.L. Wang, H. Jin, H.D. Huang, M. Hsiao and J. Y.J. Shyy*
Journal of Clinical Investigation. 2013 Mar 1;123(3):1057-67.
pseudoMap: a novel method and comprehensive resource for identification of siRNA-mediated mechanisms in human transcribed pseudogenes
W.L. Chan, W.K. Yang, H.D. Huang*, and J.G. Chang*
Database. 2013 Feb 8;2013:bat001.
Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma
W.L. Chan, C.Y. Yuo, W.K. Yang, S.Y. Huang, Y.S. Chang, C.C. Chiu, K.T. Yeh, H.D. Huang*, J.G. Chang*
Nucleic Acids Research. 2013 Apr 1;41(6):3734-47.
An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs
T.H. Chang, H.Y. Huang, J. B.K. Hsu, S.L. Weng, J.T. Horng* and H.D. Huang*
BMC Bioinformatics. 2013;14 Suppl 2:S4.
A computational approach for identifying microRNA-target interactions using high-throughput CLIP and PAR-CLIP sequencing
C.H. Chou, F.M. Lin, M.T. Chou, S.D. Hsu, T.H. Chang, S.L. Weng, S. Shrestha, C.C. Hsiao, J.H. Hung* and H.D. Huang*
BMC Genomics. 2013;14 Suppl 1:S2.
EuLoc: a web-server for accurately predict protein subcellular localization in eukaryotes by incorporating various features of sequence segments into the general form of Chou’s PseAAC
T.H. Chang, L.C. Wu, T.Y. Lee, S.P. Chen, H.D. Huang* and J.T. Horng*
Journal of Computer-Aided Molecular Design, 2013 Jan;27(1):91-103.
A new method for post Genome-Wide-Association-Study (GWAS) analysis of colorectal cancer in Taiwan
H.M. Wang, T.H. Chang, F.M. Lin, T.H. Chao, W.C. Huang, C. Liang, C.M. Chiu, W.Y. Wu, M.C. Chen, C.T. Weng, S.L. Weng, F.F. Chiang*, and H.D. Huang*
Gene. 2013 Apr 10;518(1):107-13.
The activation of directional stem cell motility by green light-emitting diode irradiation
W.K. Ong, H.F. Chen, C.T. Tsai, Y.J. Fu, Y.S. Wong, D.J. Yen, T.H. Chang, H.D. Huang, O. K.S. Lee, S. Chien, and J. H.C. Ho*
Biomaterials. 2013 Mar;34(8):1911-20.
dbPTM 3.0: an informative resource for investigating substrate site specificity and functional association of protein post-translational modifications
C.T. Lu, K.Y. Huang, M.G. Su, T.Y. Lee*, N. A. Bretaña, W.C. Chang, Y.J. Chen, and H.D. Huang*
Nucleic Acids Research. 2013 Jan;41(Database issue):D295-305.
Phosphoproteome profiling of the sexually transmitted pathogen Trichomonas vaginalis
Y.M. Yeh, K.Y. Huang, R.R.C. Gan, H.D. Huang, T.C. Wang, and P. Tang*
Journal of Microbiology, Immunology and Infection. 2013 Oct;46(5):366-73.